For over two decades Prague belongs to the top 10 of the most visited cities in Europe. It may not have quite as hip party scene as Berlin, not as many churches as Rome, as cool shopping as London or as many museums as Paris. On the other hand, it has got a fair deal of all of the above, unlike any other city.
Is the city safe?
It is just as safe as say Paris, way safer than Rome. Generally speaking, there are no "bad areas" in Prague. As anywhere in the world, beware of pickpockets in busy touristy places. It is also recommended not to stop taxis on the street as you may end up being overcharged. Rather call a cab personally, then ask the taxi driver for the price before you get in the car - approximate cost from the city center to the venue is circa 350 CZK. Or you can always use your uber application.
Will I get all the comfort I'm used to from home?
Of course, it depends on where you come from. Prague is by all standards a modern western city. You can expect clean streets and hotel rooms, drinkable and tasty tap water, WIFI internet access at most cafes, bars and restaurants and very efficient public transport (you can get virtually anywhere at any hour of the day).